Nerve Support SAP Peripheral nerves make up an intricate network that connects the brain and spinal cord to the muscles, skin, and internal organs. Diffuse damage to the peripheral nerve fibres results in peripheral neuropathy and diabetes is the commonest cause of painful peripheral neuropathy. The symptoms of peripheral neuropathy are debilitating and significantly affect the quality of life and impair physical and psychological functioning. In addition, mitochondria are subject to extensive oxidative damage, arising from nutrient deficiencies and environmental toxins. Mitochondrial dysfunction has been implicated in diabetes and neurological disorders.